Weight Loss

Intermittent Fasting May Ease the Mental Load Of Dieting

In an 18-month randomized trial, fasting and calorie restriction led to similar short-term weight loss but may have worked through different behavior patterns.

Obesity Care Is Moving Beyond GLP-1s Alone

A new peer-reviewed commentary says the next phase of obesity treatment may be more personalized, combining medications with lifestyle support, procedures and better measures of health risk.

New Obesity Drug Guidance Says Medication Is Only Part of the Plan

A new American College of Physicians guideline recommends semaglutide and tirzepatide as first-line medication options for eligible adults, but says nutrition, physical activity, side effects, access and personal health goals still matter.

Weight Loss Drugs Are Not All the Same, a New Review Suggests

A review of clinical trials found tirzepatide was linked with greater average weight loss than semaglutide or liraglutide in adults without diabetes, but the findings do not mean one medication is right for everyone.

Weight Regain May Not Erase Every Metabolic Benefit

A long-term follow-up of two lifestyle trials found that reductions in fat stored around the organs were associated with a lower risk of type 2 diabetes years later, even as average body weight returned to baseline.

More Plant Protein May Support Weight Management After Menopause

A small secondary analysis found that postmenopausal women maintained their overall protein intake while shifting toward plant-based sources and losing weight.

Experimental Oral GLP-1 Pill Shows Promise for Diabetes and Weight Loss

A once-daily pill lowered blood sugar and body weight in two phase 2 trials, but larger and longer studies are still needed before it could become an option for patients.

GLP-1-Based Medications Linked to Lower Risk of Obesity-Related Cancers

A large observational study found fewer cancer diagnoses among adults with obesity who were prescribed semaglutide or tirzepatide, but it does not prove the medications prevent cancer.

Protein Claims Are Everywhere. The Science Is More Complicated.

A critical review of common protein beliefs found promising evidence for some ideas, but major gaps remain behind many confident recommendations.

Processing Alone May Not Explain the Health Effects of Ultraprocessed Foods

A new Science Perspective argues that current clinical trials cannot isolate the effects of processing from other factors that often make certain foods easier to overeat.

Nutrition Support Matters Alongside Weight Loss Drugs

Medications such as Wegovy and Mounjaro can help people lose weight, but researchers warn that access to healthy food and ongoing care may shape long-term outcomes.

Healthier Meals May Start with Just a Few Food Swaps

A computational study found that one to three food substitutions could improve modeled nutrition quality and lower meal costs, but the approach has not yet been tested with real users.

Food Labels Don’t Tell the Whole Calorie Story

A new model suggests gut microbes help shape how much energy the body absorbs from food, adding nuance to the way scientists think about calories, fiber and metabolic health.

A Father’s Metabolic Health May Matter Before Conception

New research points to sperm signals that may help explain how paternal obesity could influence offspring metabolism, but the strongest evidence so far comes from mice.

Small Trial Tests Whether Tomato-Soy Juice Can Shift Inflammation Markers

The study does not prove that one drink can reduce disease risk, but it offers a useful look at how researchers test functional food claims in people.

Weight Loss Did Not Ease AFib Symptoms in Older Adults

A randomized clinical trial found a low-calorie diet program helped older adults with overweight lose weight safely, but it did not improve persistent atrial fibrillation symptoms or rhythm outcomes.

AI Mouse Atlas Reveals Obesity’s Wider Effects on the Body

A Nature study found obesity-related nerve and immune changes across the bodies of mice, with some matching molecular signals in human tissue.

Does Yo-Yo Dieting Really Ruin Your Metabolism?

An expert analysis argues that repeated weight loss and regain may not cause the lasting metabolic damage many people fear, though weight regain can still reverse some health gains.

Weight Loss Is Not Just About Fat Loss

A conference-presented review suggests obesity drugs and surgery may lead to a higher share of fat-free mass loss than diet and exercise, but the findings are still awaiting full journal peer review.

Mouse Study Suggests Newer GLP-1 Drugs May Alter Food Reward Pathways

A Nature study found oral GLP-1 drugs affected brain circuits tied to food motivation in mice, offering clues about why these medications may influence cravings beyond appetite alone.

Study Finds Many Major Restaurant Chains Miss Voluntary Nutrition Targets

A UK analysis of top restaurant chains found wide gaps in sugar, salt and calorie goals, raising bigger questions about whether voluntary nutrition standards are enough.

Why GLP-1 Weight Loss May Not Be Enough to Protect Muscle

A new JAMA perspective argues that while GLP-1 drugs can dramatically reduce appetite and body weight, exercise may still play a critical role in preserving muscle, supporting metabolic health and helping people maintain results long term.

Hidden Muscle Fat May Signal Heart and Metabolic Risk

A large MRI study found that fat stored inside muscle was linked to higher odds of blood pressure, blood sugar and cholesterol problems, even in adults without known disease.

Weight Gain Over Time May Be Linked to Faster Brain Aging

A 24-year study found that higher long-term BMI was associated with steeper cognitive decline in older adults, but BMI is only one piece of a much bigger brain health puzzle.

Semaglutide Linked to Fewer Heavy Drinking Days in Small Trial

A randomized trial found semaglutide reduced heavy drinking more than placebo in adults with alcohol use disorder and obesity.