Older adults at risk for dementia who participated in a coached lifestyle program saw slower cognitive decline than those who tried to make changes on their own, according to new findings from the US POINTER trial.
The large randomized clinical trial enrolled more than 2,000 adults at elevated risk for cognitive decline or dementia. One group received personalized coaching and support to adopt healthy habits across several areas of life, while a comparison group received educational materials to follow independently. The study, published in JAMA and presented at the 2025 Alzheimer’s Association International Conference, found that the structured program delivered statistically significant benefits for global cognitive function.
The coached program included:
Moderate- to high-intensity exercise several times a week;
Adherence to the MIND diet, which blends the Mediterranean and DASH diets to support brain health;
Cognitive challenges to stimulate memory and problem-solving;
Social engagement to reduce isolation and promote well-being; and
Cardiovascular health monitoring to address risk factors for heart and brain health.
This trial builds on the landmark 2015 Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) trial, which first demonstrated that multidomain lifestyle interventions could protect brain function in older adults.
By directly comparing a structured, coached program to a self-guided approach, US POINTER adds evidence that hands-on support may be key to achieving lasting brain health benefits.
The study was supported by the Alzheimer’s Association, which partnered in the trial’s design and implementation, and by the US Highbush Blueberry Council, which provided monthly rebates for participants in the structured program.